Latency In vitro using Irradiated Herpes Simplex Virus
نویسندگان
چکیده
منابع مشابه
Irradiated Herpes Simplex Virus
Aphidicolin is a potent inhibitor of both host cell DNA polymerase a and herpes simplex virus (HSV)induced DNA polymerase but has no effect on DNA polymerases ,B and y of host cells. By using an aphidicolin-resistant mutant (Aphr) of HSV, a possible involvement of DNA polymerase a in host cell reactivation of UV-damaged HSV was studied. Plaque formation by UV-irradiated Aph' was markedly inhibi...
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L cells lacking thymidine kinase (TK) activity (Ltkcells) have been stably transformed to a TK-positive phenotype by infection with ultraviolet-irradiated herpes simplex virus (HSV-UV). The highest frequency of the Ltkto Ltk+ transformation observed in these experiments was approximately 10-3, whereas no measurable transformation was observed (less than 10-8) in the absence of HSV-UV infection....
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The clinical manifestations of herpes simplex virus infection generally involve a mild and localized primary infection followed by asymptomatic (latent) infection interrupted sporadically by periods of recrudescence (reactivation) where virus replication and associated cytopathologic findings are manifest at the site of initial infection. During the latent phase of infection, viral genomes, but...
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Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral culture in thediagnosis of herpes simplex virus infection in patients clinicallysuspected to...
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Background and Aims: The latency-associated transcript (LAT) transcribed by latent Herpes Simplex Virus type-1 in neuron cells are able to influence their host cell pathways. While the most of previous studies were focused on anti-apoptotic effects of LAT, our investigation is making an effort to explore LAT potency on cell cycle pathway in neuroblastoma cell lines. Methods: The evaluation of L...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1981
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-52-1-113